近年代表论著 |
1．Feifei Yang, Tao Zhang, Haigang Wu, Yang Yang, Ning Liu, Liwen Qin, Jingjie Li, Beier Jiang, Qiang Li, Xiufeng Pang, Zhengfang Yi, Mingyao Liu and Yihua Chen. Design and Optimization of Novel Hydroxamate-Based HDAC Inhibitors of Bis-substituted Aromatic Amides Bearing Potent Activities against Tumor Growth and Metastasis. J. Med. Chem. 2014, Nov 26; 57, 9357 −9369 (IF = 6.256) 2. Feifei Yang, Shihong Peng, Yunqi Li, Liqiang Su, Yangrui Peng, Jing Wu, Huang Chen, Mingyao Liu, Zhengfang Yi and Yihua Chen.A hybrid of thiazolidinone with the hydroxamate scaffold for developing novel histone deacetylase inhibitorswith antitumor activities Org. Biomol. Chem. 2016, Feb 7;14(5): 1727–1735 (IF = 3.564) 3. Feifei Yang, Peipei Shan, Na Zhao, Di Ge, Kongkai Zhu, Cheng-shi Jiang, Peifeng Li, Hua Zhang Development of hydroxamate-based histone deacetylase inhibitors containing 1,2,4-oxadiazole moiety core with antitumor activities Bioorg Med Chem Lett. 2019 Jan 1;29(1):15-21(IF = 2.442) 4. Jing Wu1, Linxi Yu1, Feifei Yang1, Jingjie Li, Peng Wang, Wenbo Zhou, Liwen Qin,Yunqi Li, Jian Luo, Zhengfang Yi, Mingyao Liu, Yihua Chen. Optimization of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives as potent antitumor growth and metastasis agents. Euro. J. Med. Chem. 2014 Jun 10; 80:340-351.（IF = 4.519) 5. Tao Zhang, Jingjie Li,Yuan He, Feifei Yang, Yun Hao, Wangrui Jin, Jing Wu, Zhenliang Sun, Yunqi Li,Yihua Chen, Zhengfang Yi & Mingyao Liu A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat Commun. 2018 Sep 13;9(1):3726. IF = 12.353) 6. Jingjie Li, Tao Zhang, Feifei Yang, Yuan He, Fujun Dai, Dan Gao, Yihua Chen, Mingyao Liu, and Zhengfang Yi.Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, through down-regulating EGFR expression. Br J Pharmacol. 2015 Aug;172(15):3817-30. (IF = 4.99) 7. Yongrui Liu, Yuan He, Feifei Yang, Xiaonan Cong, Jinhua Wang, Shihong Peng, Dan Gao, Weifang Wang, Liping Lan, Xuexiang Ying, Mingyao Liu, Yihua Chen, Zhengfang Yi A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling Science China Life Sciences. February 2017, Volume 60, Issue 2, pp 202–214 (IF=2.29) 8. Tao Zhang, Yihua Chen, Jingjie Li, Feifei Yang，Haigang Wu, Fujun Dai, Meichun Hu, Xiaoling Lu, Yi Peng, Mingyao Liu, Yongxiang Zhao and Zhengfang Yi. Antitumor Action of a Novel Histone Deacetylase Inhibitor, YF479, in Breast Cancer. Neoplasia 2014 Aug; 16(8):665-77.(IF = 5.398) 9. Cong Zheng, Yuanzhang Fang, Weiguang Tong,Guoliang Li, Haigang Wu,Wenbo Zhou, Qingxiang Lin, Feifei Yang， Zhengfeng Yang, Peng Wang,Yangrui Peng, Xiufeng Pang, Zhengfang Yi, Jian Luo,*Mingyao Liu,*and Yihua Chen*. Synthesis and Biological Evaluation of Novel Tetrahydro-β-carboline Derivatives as Antitumor Growth and Metastasis Agents through Inhibiting the Transforming Growth Factor‑β Signaling Pathway. J. Med. Chem. 2014, 57, 600−612.(IF = 6.256) 10. 陈益华、刘明耀、杨飞飞、张涛、易正芳、李静婕。氮原子多取代的芳香酰胺类小分子有机化合物及其衍生物、用途及其制备方法。授权中国发明专利，专利号：ZL 2012 l 0174929.7 11. 陈益华、刘明耀、易正芳、杨飞飞、代付军。一类酰基吡咯类小分子有机化合物及其衍生物、用途及其制备方法。授权中国发明专利，专利号：ZL 2014 1 0653320.7 12. 陈益华、刘明耀、杨洋、张涛、杨飞飞、吕方、易正芳、逄秀凤。杂环取代异羟肟酸类芳香酰胺化合物或其药学上可接受的盐、及其制备方法和应用。中国发明专利申请号：201410164011.3 13. 陈益华、刘明耀、李静婕、杨飞飞、易正芳、彭世鸿。一类含有噻唑啉酮结构的异羟肟酸类小分子有机化合物及其衍生物、用途及其制备方法。中国发明专利申请号：201410628974.4 14. 易正芳、刘永瑞、贺源、杨飞飞、陈益华、刘明耀 小分子化合物YF-452及其在制备抗血管新生药物中的应用。中国发明专利申请号：201610011401.6 15. 张华， 杨飞飞， 赵娜， 葛迪， 韩丽娜， 李佳，苏明波，江成世， 宋佳丽， 藏奕. 一类含有四氢-β-咔碄结构的异羟肟酸类化合物、用途及其制备方法. 中国发明专利申请号：201810006675.5 16. 张华，杨飞飞，单佩佩，赵娜，江成世，宋佳丽，葛迪，韩丽娜. 一类含有香豆素结构的异羟肟酸类化合物、用途及其制备方法. 中国发明专利申请号：201810364677.1 17. 张华，杨飞飞，单佩佩，赵娜，周志侠, 张静. 一类含有噁二唑结构的氮原子双取代异羟肟酸类化合物、用途及其制备方法. 中国发明专利申请号：201810528152.7 |